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Fractionation is an excellent separation process under which a certain quantity of a mixture (solid, solute, liquid, suspension or isotope) is divided up in a number of smaller quantities (fractions) in which the composition changes in accordance to a gradient. Fractions are collected based on differences in a particular property of the distinctive components. A common characteristics in fractionations is the requirement to find an optimum among the amount of fractions accumulated and the desired purity in each and every fraction..

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